Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807789 | 0.76 | — | — | |
| SCHEMBL9550092 | 0.76 | KDM4E (0.40) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL1999768 | 0.74 | — | — | |
| SCHEMBL10961212 | 0.73 | KDM4E (0.38) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL8722184 | 0.73 | PIK3CD (0.41) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL7276937 | 0.73 | KDM4E (0.38) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL11593071 | 0.70 | PIK3CD (0.39) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL7001468 | 0.70 | PIK3CD (0.39) | KDM4EPIK3CDGRM2NQO2PER2 | |
| SCHEMBL8593693 | 0.70 | — | — | |
| SCHEMBL6645268 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |