Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909610 | 0.89 | KDM4E (0.33) | HTR2AHTR2C | |
| SCHEMBL11623769 | 0.80 | KDM4E (0.33) | — | |
| SCHEMBL10044415 | 0.79 | PTGS2 (0.48) | — | |
| SCHEMBL11420088 | 0.79 | MEN1 (0.37) | — | |
| SCHEMBL8582195 | 0.76 | CTSS (0.38) | — | |
| SCHEMBL24076248 | 0.75 | KDM4E (0.44) | HTR2AHTR2CPDE4APDE4BPDE4C | |
| SCHEMBL12877231 | 0.75 | TSHR (0.37) | — | |
| SCHEMBL5088833 | 0.71 | KDM4E (0.46) | — | |
| SCHEMBL104990 | 0.70 | ALDH1A1 (0.58) | HTR2CPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29892424 | 0.70 | TP53 (0.34) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739134-A | TREATMENT OF GASTROINTESTINAL DISORDERS, DECREASED PERISTALSIS | JANSSEN PHARMACETUICA N.V. (BE) | 1998-04-14 | — | — | US | disclosed |
| CN-1034502-C | N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin) carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1997-04-09 | — | — | CN | disclosed |
| US-5616738-A | A 7-CARBOXYBENZOFURAN INTERMEDIATE FOR DRUGS HAVING GASTROINTESTINAL MOTILITY STIMULATING PROPERTIES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-04-01 | — | — | US | disclosed |
| US-5616583-A | GASTROINTESTINAL MOTILITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-04-01 | — | — | US | disclosed |
| US-5610157-A | N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-11 | — | — | US | disclosed |
| US-5602129-A | GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-11 | — | — | US | disclosed |
| US-5576448-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS, ANTIPSYCHOTICS OR NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-11-19 | — | — | US | disclosed |
| US-5565582-A | GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-15 | — | — | US | disclosed |
| US-5554772-A | CHEMICAL INTERMEDIATES; GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-10 | — | — | US | disclosed |
| US-5552553-A | CHEMICAL INTERMEDIATES FOR LAXATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| US-5536733-A | GASTROINTESTINAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-16 | — | — | US | disclosed |
| US-5521314-A | CHEMICAL INTERMEDIATES FOR CENTRAL NERVOUS SYSTEM, ANTIEMETICS, ANTIPSYCHOTIC AGENTS OR NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| EP-0389037-B1 | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-09-20 | — | — | EP | disclosed |
| US-5374637-A | Stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-20 | — | — | US | disclosed |
| EP-0220735-B1 | 3(2H)-PYRIDAZINONE DERIVATIVES, A PROCESS AND INTERMEDIATES FOR PREPARING THEM AND MEDICAMENTS CONTAINING THEM AND/OR OTHER 3(2H)-PYRIDAZINONE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1993-05-19 | — | — | EP | disclosed |
| CN-1045781-A | N-(3-hydroxy-4-piperidinyl base) (Dihydrobenzofuranes, dihydro-2H-chromene or dihydrobenzo two English) carboxamides derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1990-10-03 | — | — | CN | disclosed |
| EP-0389037-A1 | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-26 | — | — | EP | disclosed |
| US-4826845-A | HYPOTENSIVE, ADRENERGIC BLOCKING AGENTS | RICHTER GEDEON VEGYESZETI GYAR T.R. (HU) | 1989-05-02 | — | — | US | disclosed |
| EP-0220735-A2 | 3(2H)-pyridazinone derivatives, a process and intermediates for preparing them and medicaments containing them and/or other 3(2H)-pyridazinone derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1987-05-06 | — | — | EP | disclosed |