Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 14/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136405 | 0.85 | KCNK2 (0.61) | SCN2AKCNK2HTR3AHRH4 | |
| SCHEMBL8842601 | 0.83 | PIK3CA (0.46) | SCN2AKCNK2 | |
| SCHEMBL5070744 | 0.79 | KCNK2 (0.54) | SCN2AKCNK2PTPN11HTR3AHRH4 | |
| SCHEMBL7286933 | 0.78 | SCN2A (0.71) | SCN2AKCNK2PTPN11SCN9A | |
| SCHEMBL170312 | 0.73 | SCN2A (0.43) | SCN2AKCNK2SCN9A | |
| SCHEMBL6049502 | 0.70 | SCN2A (0.39) | SCN2AKCNK2PTPN11SCN9A | |
| SCHEMBL7273354 | 0.69 | HRH4 (0.50) | SCN2AKCNK2HTR3AHRH4 | |
| SCHEMBL134764 | 0.69 | KCNK2 (0.67) | SCN2AKCNK2PTPN11HTR3AHRH4 | |
| SCHEMBL7282241 | 0.66 | MTOR (0.48) | — | |
| SCHEMBL7273080 | 0.66 | DRD2 (0.40) | SCN2AKCNK2PTPN11HTR3AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | claimed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |