Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440609 | 0.84 | NPC1 (0.57) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL5684870 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL1201233 | 0.80 | NPC1 (0.51) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL4131049 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5447489 | 0.79 | NPC1 (0.50) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL12235253 | 0.77 | NPC1 (0.51) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL14386089 | 0.77 | NPC1 (0.51) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL5834937 | 0.77 | NPC1 (0.51) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL7269210 | 0.75 | NPC1 (0.50) | NPC1RAB9AKMT2AALOX5HTR1A | |
| SCHEMBL920229 | 0.75 | NPC1 (0.50) | NPC1RAB9AKMT2AALOX5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |