Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684870 | 1.00 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL5447489 | 0.98 | NPC1 (0.50) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| SCHEMBL4440609 | 0.87 | NPC1 (0.57) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL4131049 | 0.83 | — | — | |
| SCHEMBL3229012 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| SCHEMBL14525329 | 0.82 | NPC1 (0.53) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| SCHEMBL7277256 | 0.80 | NPC1 (0.46) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| Methylamine SCHEMBL6327312 | 0.80 | SLC6A2 (0.47) | NPC1RAB9AKMT2AHTR1ASLC6A2 | |
| SCHEMBL1200723 | 0.80 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ACES2 | |
| SCHEMBL1232311 | 0.80 | NPC1 (0.55) | NPC1RAB9AKMT2AHTR1ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107488163-A | The preparation method of (2 thienyl) 1 propyl alcohol of one kind (S) 3 N, N disubstituted amidos 1 | 天台宜生生化科技有限公司 | 2017-12-19 | — | — | CN | claimed |
| US-7893281-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2011-02-22 | — | — | US | claimed |
| US-20090286997-A1 | PROCESS FOR PREPARING ARYLAMINOPROPANOLS | LANXESS DEUTSCHLAND GMBH (DE) | 2009-11-19 | — | — | US | claimed |
| EP-2060559-A1 | Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers | Cadila Pharmaceuticals Limited (IN) | 2009-05-20 | — | — | EP | claimed |
| CN-101012220-A | Method of preparing N-methyl-3-hydroxy-3-(2-thiophene)propylamine | UNIV TIANJIN (CN) | 2007-08-08 | — | — | CN | claimed |
| US-20050107621-A1 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-05-19 | — | — | US | claimed |
| EP-1486493-A1 | 3-HYDROXY-3-(2-THIENYL)PROPIONAMIDE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING 3-AMINO-1-(2-THIENYL)-1-PROPANOL COMPOUND THEREFROM | Mitsubishi Chemical Corporation (JP) | 2004-12-15 | — | — | EP | claimed |
| WO-2004031168-A2 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINO-1-(2-THIENYL)-1-PROPANOL DERIVATIVES | LONZA AG (CH) | 2004-04-15 | — | — | WO | claimed |
| CN-114437022-A | Preparation method of duloxetine intermediate | 浙江拓普药业股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| US-20200087249-A1 | Inhibitors of Quorum Sensing Receptor LasR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2020-03-19 | — | — | US | disclosed |
| US-20190119201-A1 | Inhibitors of Quorum Sensing Receptor LasR | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2019-04-25 | — | — | US | disclosed |
| CN-109485634-A | A kind of preparation method of S- (+) duloxetine hydrochloride intermediate | 成都倍特药业有限公司 | 2019-03-19 | — | — | CN | disclosed |
| CN-107488163-A | The preparation method of (2 thienyl) 1 propyl alcohol of one kind (S) 3 N, N disubstituted amidos 1 | 天台宜生生化科技有限公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-105274069-A | Alcohol dehydrogenase and uses thereof in synthesis of Duloxetine intermediate | NANJING ABIOCHEM BIOMEDICAL TECHNOLOGY CO LTD | 2016-01-27 | — | — | CN | disclosed |
| US-20030171592-A1 | Process for producing optically active amino alcohols and intermediates therefore | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 2003-09-11 | — | — | US | disclosed |
| WO-2003070720-A1 | PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES | DEGUSSA AG (DE) | 2003-08-28 | — | — | WO | disclosed |
| EP-1308435-A2 | Process for producing optically active amino alcohols | Kanto Kagaku Kabushiki Kaisha (JP) | 2003-05-07 | — | — | EP | disclosed |
| EP-0648768-B1 | Preparation of 3-dihaloacetyl oxazolidines | MONSANTO CO (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5428172-A | Preparation of 3-dihaloacetyl oxazolidines | MONSANTO COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0648768-A1 | Preparation of 3-dihaloacetyl oxazolidines | MONSANTO COMPANY (US) | 1995-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107621-A1 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same | APEH, AADAC, KMO | NPC1 3667/4885RAB9A 3805/4885KMT2A 1564/4885 |
| US-20030171592-A1 | Process for producing optically active amino alcohols and intermediates therefore | ADH1A, NOS1, ADH5 | NPC1 3259/4885RAB9A 2501/4885KMT2A 1865/4885 |
| US-20200087249-A1 | Inhibitors of Quorum Sensing Receptor LasR | FFAR1, CYSLTR1, LPAR1 | NPC1 3275/4885RAB9A 2781/4885KMT2A 3939/4885 |
| US-20090286997-A1 | PROCESS FOR PREPARING ARYLAMINOPROPANOLS | AHR, CYP1A1, CYP1A2 | NPC1 2343/4885RAB9A 3297/4885KMT2A 746/4885 |
| US-20190119201-A1 | Inhibitors of Quorum Sensing Receptor LasR | FFAR1, CYSLTR1, LPAR1 | NPC1 3275/4885RAB9A 2781/4885KMT2A 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.