Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856300 | 1.00 | S1PR1 (0.49) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL7278231 | 1.00 | S1PR1 (0.49) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL1906108 | 0.94 | S1PR1 (0.55) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL28211526 | 0.94 | S1PR1 (0.49) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL7269957 | 0.93 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL7269965 | 0.93 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL9155196 | 0.88 | S1PR1 (0.41) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL4375455 | 0.88 | S1PR1 (0.41) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL14509645 | 0.84 | ADRA1D (0.37) | S1PR1S1PR3S1PR5S1PR4SPHK2 | |
| SCHEMBL12643455 | 0.84 | S1PR1 (0.51) | S1PR1S1PR3S1PR5S1PR4SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407137-B1 | Benzazine compounds and pharmaceutical uses thereof | YOSHITOMI PHARMACEUTICAL (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5185333-A | Dopamine D2 receptor blocking agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| EP-0407137-A2 | Benzazine compounds and pharmaceutical uses thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-01-09 | — | — | EP | disclosed |