Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270151 | 0.90 | KMO (0.56) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7270859 | 0.81 | POLB (0.41) | TSHRALDH1A1USP2POLBTP53 | |
| SCHEMBL7278244 | 0.78 | CYP3A4 (0.54) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL16897914 | 0.77 | TSHR (0.69) | TSHRCYP3A4CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL7268703 | 0.74 | KMO (0.51) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL31444652 | 0.72 | TSHR (0.46) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL18264378 | 0.71 | KMO (0.50) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7278012 | 0.71 | ALDH1A1 (0.38) | TSHRCYP2C19ALDH1A1USP2CYP2C9 | |
| SCHEMBL5799939 | 0.71 | KMT2A (0.47) | TSHRKMOCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7270138 | 0.69 | KMO (0.56) | TSHRKMOCYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445467-A1 | Renin inhibitors and antiviral agents | Beecham Group p.l.c. (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0411751-A1 | Renin inhibitory peptides | Beecham Group p.l.c. (GB) | 1991-02-06 | — | — | EP | disclosed |