Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278012 | 0.90 | ALDH1A1 (0.38) | POLBLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7278250 | 0.81 | TSHR (0.45) | POLBALDH1A1USP2TSHRTP53 | |
| SCHEMBL7270855 | 0.78 | MAPT (0.44) | POLBLMNATDP1SMN1; SMN2MAPT | |
| SCHEMBL7270181 | 0.74 | POLB (0.46) | POLBLMNATDP1SMN1; SMN2MAPT | |
| SCHEMBL7280026 | 0.73 | NPSR1 (0.62) | POLBLMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7270151 | 0.71 | KMO (0.56) | POLBALDH1A1L3MBTL1USP2TSHR | |
| SCHEMBL9850703 | 0.70 | ALDH1A1 (0.46) | POLBLMNATDP1SMN1; SMN2MAPT | |
| SCHEMBL9845852 | 0.70 | NPSR1 (0.41) | POLBLMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7278264 | 0.69 | MAPT (0.42) | TDP1SMN1; SMN2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL24796120 | 0.65 | MAPT (0.54) | POLBSMN1; SMN2MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411751-A1 | Renin inhibitory peptides | Beecham Group p.l.c. (GB) | 1991-02-06 | — | — | EP | disclosed |