Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7271020 | 0.99 | HRH3 (0.41) | HRH3FAAHHTR2ADRD3HTR3A | |
| SCHEMBL7273121 | 0.87 | FAAH (0.44) | HRH3FAAHHTR2ADRD3HTR3A | |
| Hydrochloric Acid SCHEMBL7279858 | 0.86 | FAAH (0.44) | HRH3FAAHHTR2ADRD3HTR3A | |
| SCHEMBL7272330 | 0.85 | DRD2 (0.44) | HRH3FAAHHTR2ADRD3HTR3A | |
| Hydrochloric Acid SCHEMBL7280061 | 0.84 | HTR2A (0.43) | HRH3FAAHHTR2ADRD3HTR3A | |
| SCHEMBL7271094 | 0.83 | FAAH (0.47) | FAAHHTR2ADRD3HTR3AMAOA | |
| Hydrochloric Acid SCHEMBL7271028 | 0.82 | FAAH (0.46) | FAAHHTR2ADRD3HTR3AMAOA | |
| SCHEMBL7278431 | 0.76 | FAAH (0.46) | FAAHHTR3A | |
| SCHEMBL7280850 | 0.75 | FAAH (0.44) | FAAHHTR2ADRD3HTR3A | |
| Hydrochloric Acid SCHEMBL7280489 | 0.75 | FAAH (0.45) | FAAHHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |