Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7280418 | 0.99 | L3MBTL1 (0.45) | FAAHL3MBTL1HTR3AHTR2CHTR2B | |
| SCHEMBL7279325 | 0.91 | ALDH1A1 (0.44) | L3MBTL1HTR3AHTR2CHTR2BPOLB | |
| Hydrochloric Acid SCHEMBL7272125 | 0.90 | L3MBTL1 (0.45) | L3MBTL1HTR3AHTR2CHTR2BPOLB | |
| SCHEMBL7271094 | 0.88 | FAAH (0.47) | FAAHHTR3AHTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL7271028 | 0.87 | FAAH (0.46) | FAAHHTR3AHTR2CHTR2BHTR2A | |
| SCHEMBL7272330 | 0.78 | DRD2 (0.44) | FAAHHTR3AHTR2ADRD3SLC6A4 | |
| SCHEMBL7282325 | 0.78 | ALDH1A1 (0.47) | HTR3AHTR2CHTR2BHTR2ADRD3 | |
| SCHEMBL7273121 | 0.78 | FAAH (0.44) | FAAHHTR3APOLBHTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL7280061 | 0.77 | HTR2A (0.43) | FAAHHTR3AHTR2ADRD3SLC6A4 | |
| Hydrochloric Acid SCHEMBL7271099 | 0.77 | ALDH1A1 (0.46) | HTR3AHTR2CHTR2BHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |