Benalaxyl

Benalaxyl

SCHEMBL727907

COC(=O)C(C)N(C(=O)c1ccco1)c1c(C)cccc1C.COC(=O)[C@@H](C)N(C(=O)Cc1ccccc1)c1c(C)cccc1C

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.56
MEN1 O00255 4/20 0.56
PLA2G1B P04054 1/20 0.56
HTT P42858 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
ATG4B Q9Y4P1 1/20 0.56
S1PR4 O95977 1/20 0.42
OPRM1 P35372 4/20 0.42
TRPM8 Q7Z2W7 1/20 0.42
RORC P51449 1/20 0.39
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
MAPK1 P28482 1/20 0.38
SIRT5 Q9NXA8 1/20 0.38
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benalaxyl SCHEMBL4297556 1.00 KMT2A (0.56) KMT2AMEN1PLA2G1BHTTNPSR1
Furalaxyl SCHEMBL9661285 0.90 MEN1 (0.60) KMT2AMEN1PLA2G1BHTTNPSR1
Furalaxyl SCHEMBL54624 0.90 MEN1 (0.60) KMT2AMEN1PLA2G1BHTTNPSR1
Furalaxyl SCHEMBL22528 0.90 MEN1 (0.60) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL54808 0.89 KMT2A (0.61) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL2528870 0.89 KMT2A (0.61) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL21674 0.89 KMT2A (0.61) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL41642 0.89 KMT2A (0.61) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL8818251 0.89 KMT2A (0.61) KMT2AMEN1PLA2G1BHTTNPSR1
Benalaxyl SCHEMBL7182610 0.88 KMT2A (0.60) KMT2AMEN1PLA2G1BHTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1622453-B1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS MAKHTESHIM CHEM WORKS LTD (IL) 2011-05-11 EP claimed
JP-4657199-B2 2011-03-23 JP claimed
JP-2006525250-A 2006-11-09 JP claimed
EP-1622453-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS Bayer CropScience AG (DE) 2006-02-08 EP claimed
WO-2004095929-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2004-11-11 WO claimed
WO-2024069628-A1 CONCENTRATED AGROCHEMICAL COMPOSITIONS OF ANTHRANILIC DIAMIDES ADAMA MAKHTESHIM LTD. (IL) 2024-04-04 WO disclosed
US-11026425-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ADAMA MAKHTESHIM LTD. (IL) 2021-06-08 US disclosed
US-20190350204-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2019-11-21 US disclosed
US-10412966-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ADAMA MAKHTESHIM LTD. (IL) 2019-09-17 US disclosed
US-20170258088-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS ADAMA MAKHTESHIM LTD. (IL) 2017-09-14 US disclosed
US-9642366-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ADAMA MAKHTESHIM LTD. (IL) 2017-05-09 US disclosed
US-20150264930-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS ADAMA MAKHTESHIM LTD. (IL) 2015-09-24 US disclosed
US-9072300-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ADAMA MAKHTESHIM LTD. (IL) 2015-07-07 US disclosed
US-20130203708-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS ADAMA MAKHTESHIM LTD. (IL) 2013-08-08 US disclosed
US-8426605-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds MAKHTESHIM CHEMICAL WORKS, LTD. (IL) 2013-04-23 US disclosed
EP-1622453-B1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS MAKHTESHIM CHEM WORKS LTD (IL) 2011-05-11 EP disclosed
US-20070155706-A1 Active substance combinations that have nemticidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ADAMA MAKHTESHIM LTD. (IL) 2007-07-05 US disclosed
EP-1622453-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS Bayer CropScience AG (DE) 2006-02-08 EP disclosed
WO-2004095929-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190350204-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885
US-10412966-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885
US-11026425-B2 Active substance combinations that have nematicidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885
US-20070155706-A1 Active substance combinations that have nemticidal, insecticidal, and fungicidal properties and are based on trifluorobutenyl compounds ACHE, AADAC, DDT KMT2A 3165/4885MEN1 3070/4885PLA2G1B 1482/4885
US-20170258088-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885
US-20150264930-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885
US-20130203708-A1 ACTIVE SUBSTANCE COMBINATIONS THAT HAVE NEMATICIDAL, INSECTICIDAL, AND FUNGICIDAL PROPERTIES AND ARE BASED ON TRIFLUOROBUTENYL COMPOUNDS DDT, ACHE, AADAC KMT2A 2967/4885MEN1 3318/4885PLA2G1B 811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.