Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282602 | 0.87 | MEN1 (0.56) | CYP2D6POLBMAPTMEN1KMT2A | |
| SCHEMBL7288820 | 0.85 | CYP2D6 (0.64) | CYP2D6KDM4EPOLBMAPTMEN1 | |
| SCHEMBL7288557 | 0.83 | CYP2D6 (0.53) | CYP2D6MAPTMEN1KMT2ATP53 | |
| SCHEMBL7288797 | 0.82 | CYP2D6 (0.65) | CYP2D6KDM4EPOLBMEN1KMT2A | |
| SCHEMBL7280914 | 0.82 | CYP2D6 (0.52) | CYP2D6KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7291959 | 0.81 | KMT2A (0.51) | CYP2D6KDM4EMAPTMEN1KMT2A | |
| SCHEMBL10835709 | 0.81 | CYP2D6 (0.66) | CYP2D6KDM4EPOLBMEN1KMT2A | |
| SCHEMBL7279370 | 0.79 | ALDH1A1 (0.60) | CYP2D6KDM4EPOLBMAPTMEN1 | |
| SCHEMBL7282228 | 0.77 | CYP2D6 (0.52) | CYP2D6KDM4EPOLBMAPTMEN1 | |
| SCHEMBL7278993 | 0.77 | USP2 (0.55) | CYP2D6KDM4EPOLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |