Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ADH5 | P11766 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280036 | 0.81 | PDE3B (0.59) | PDE3BPDE3ATSHRCYP3A4LMNA | |
| SCHEMBL11238845 | 0.81 | KMT2A (0.45) | LMNAPDE4BMEN1KMT2ATHRB | |
| SCHEMBL11400866 | 0.77 | KMT2A (0.56) | LMNAPDE4BMEN1KMT2ATHRB | |
| SCHEMBL11149657 | 0.76 | KMT2A (0.58) | LMNAMEN1KMT2ATHRB | |
| SCHEMBL11397697 | 0.76 | THRB (0.45) | LMNAPDE4BMEN1KMT2ATHRB | |
| SCHEMBL11240512 | 0.73 | PDE4B (0.52) | LMNAPDE4BMEN1KMT2ATHRB | |
| SCHEMBL11242218 | 0.72 | PDE4B (0.48) | PDE3BPDE3ALMNAPDE4BMEN1 | |
| SCHEMBL11400133 | 0.71 | ALDH1A1 (0.45) | LMNAPDE4BMEN1KMT2ATHRB | |
| SCHEMBL11401967 | 0.71 | TP53 (0.50) | LMNAPDE4BMEN1KMT2ATHRB | |
| Imazodan SCHEMBL148436 | 0.69 | PDE3B (1.00) | PDE3BPDE3ATSHRCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |