Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429204 | 0.86 | SPHK1 (0.41) | SPHK1SPHK2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7289664 | 0.83 | CHRM2 (0.43) | OPRD1OPRM1OPRK1 | |
| SCHEMBL7282061 | 0.82 | EPHX1 (0.54) | OPRD1ALDH1A1 | |
| SCHEMBL7292487 | 0.81 | KDM4E (0.45) | OPRD1OPRM1GLSALDH1A1OPRK1 | |
| SCHEMBL10837604 | 0.80 | OPRD1 (0.37) | OPRD1OPRM1GLSOPRK1 | |
| SCHEMBL7278715 | 0.79 | OPRD1 (0.50) | OPRD1OPRM1 | |
| SCHEMBL7278992 | 0.76 | CYP2D6 (0.58) | OPRD1OPRM1ALDH1A1 | |
| SCHEMBL793646 | 0.76 | OPRD1 (0.60) | OPRD1OPRM1GLS | |
| SCHEMBL7279116 | 0.76 | OPRD1 (0.44) | OPRD1OPRM1GLSALDH1A1 | |
| SCHEMBL7288846 | 0.76 | CHRM2 (0.55) | OPRD1OPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |