Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288835 | 0.97 | HTR1A (0.55) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7281848 | 0.91 | HTR1A (0.64) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7291493 | 0.89 | DRD4 (0.56) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL7279846 | 0.88 | HTR1A (0.60) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7282164 | 0.87 | HTR1A (0.58) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7281117 | 0.87 | HTR1A (0.63) | HTR1AHTR2ADRD2DRD3HTR7 | |
| SCHEMBL7289690 | 0.86 | CYP1A2 (0.54) | HTR1ADRD2DRD3SLC6A4HTR7 | |
| SCHEMBL7278140 | 0.86 | HTR1A (0.55) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7281710 | 0.86 | HTR1A (0.55) | HTR1AHTR2ADRD2DRD3SLC6A4 | |
| SCHEMBL7289056 | 0.86 | HTR1A (0.57) | HTR1AHTR2ADRD2DRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114603-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1984-08-01 | — | — | EP | disclosed |