Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | PRCP | P42785 | 1/20 | 0.56 |
| ▸ | EBP | Q15125 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | DRD5 | P21918 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281777 | 0.97 | DRD4 (0.55) | DRD4DRD3SIGMAR1DRD2NFKB1 | |
| SCHEMBL11117567 | 0.94 | SIGMAR1 (0.58) | DRD4DRD3SIGMAR1DRD2NFKB1 | |
| Bromide SCHEMBL11120920 | 0.93 | SIGMAR1 (0.57) | DRD4DRD3SIGMAR1DRD2NFKB1 | |
| SCHEMBL7279314 | 0.89 | DRD4 (0.55) | DRD4DRD3SIGMAR1DRD2NFKB1 | |
| SCHEMBL7282059 | 0.89 | DRD4 (0.55) | DRD4DRD3SIGMAR1DRD2NFKB1 | |
| SCHEMBL7280108 | 0.89 | HTR1A (0.59) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7281848 | 0.88 | HTR1A (0.64) | DRD4DRD3DRD2HTR1ADRD1 | |
| SCHEMBL7288835 | 0.86 | HTR1A (0.55) | DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7288453 | 0.85 | HTR1A (0.63) | DRD2HTR1AHTR2A | |
| SCHEMBL7279846 | 0.85 | HTR1A (0.60) | DRD4DRD3DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114603-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1984-08-01 | — | — | EP | disclosed |