Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 10/20 | 0.39 |
| ▸ | METAP1 | P53582 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289820 | 0.83 | REN (0.48) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7296285 | 0.80 | REN (0.48) | RENMETAP2METAP1CTSD | |
| SCHEMBL7294582 | 0.80 | REN (0.48) | RENMETAP2METAP1CTSD | |
| SCHEMBL7294879 | 0.75 | REN (0.43) | RENMETAP2METAP1CTSD | |
| Acetic Acid SCHEMBL7294621 | 0.75 | REN (0.46) | RENMETAP2METAP1CTSD | |
| SCHEMBL7274162 | 0.73 | REN (0.55) | RENMETAP2METAP1KMT2A | |
| Hydrochloric Acid SCHEMBL7396856 | 0.72 | METAP2 (0.65) | RENMETAP2METAP1CTSD | |
| SCHEMBL12507498 | 0.72 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL7301592 | 0.71 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL8910518 | 0.71 | REN (0.49) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506356-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| US-5481036-A | RENIN INHIBITORS, HYPOTENSIVE AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-01-02 | — | — | US | disclosed |
| US-5319082-A | N-acylamino acid derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5240924-A | Dipeptide hypotensives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-08-31 | — | — | US | disclosed |
| US-5122523-A | Hypotensive agents | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1992-06-16 | — | — | US | disclosed |
| EP-0309766-A2 | N-acylamino acid derivatives and their use | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |