Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281223 | 0.81 | CYP11B1 (0.51) | FFAR1MAPTLMNARPS6KA3ALDH1A1 | |
| SCHEMBL8575966 | 0.78 | CYP11B1 (0.40) | FFAR1PTK2NOS2PLA2G4APTPN1 | |
| SCHEMBL8560440 | 0.72 | CCNC (0.43) | PTPN1RPS6KA3 | |
| Hydrochloric Acid SCHEMBL7275608 | 0.72 | ITGB3 (0.48) | — | |
| SCHEMBL7282163 | 0.71 | PTPN1 (0.37) | PTPN1LMNARPS6KA3ALDH1A1TDP1 | |
| SCHEMBL7384638 | 0.71 | HRH3 (0.39) | FFAR1NOS2PTPN1RPS6KA3 | |
| SCHEMBL7385562 | 0.67 | HRH3 (0.41) | PTPN1RPS6KA3ALDH1A1 | |
| SCHEMBL7274756 | 0.67 | MAPT (0.43) | MAPTALDH1A1TDP1 | |
| Methyl 3-Phenylpropanoate SCHEMBL27447160 | 0.67 | TDP1 (0.66) | FFAR1MAPTLMNAALDH1A1TDP1 | |
| SCHEMBL22922181 | 0.67 | CYP4F2 (0.59) | MAPTLMNAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |