Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733367 | 1.00 | MME (0.62) | MMERAB9AGAAACESIGMAR1 | |
| SCHEMBL7280398 | 1.00 | MME (0.62) | MMERAB9AGAAACESIGMAR1 | |
| SCHEMBL11008763 | 0.92 | MME (0.68) | MMEACEKMT2ASMN1; SMN2CPA1 | |
| SCHEMBL9864316 | 0.91 | RAB9A (0.52) | MMERAB9AGAAACESIGMAR1 | |
| SCHEMBL9733346 | 0.91 | RAB9A (0.52) | MMERAB9AGAAACESIGMAR1 | |
| SCHEMBL9864327 | 0.91 | RAB9A (0.52) | MMERAB9AGAAACESIGMAR1 | |
| SCHEMBL7321485 | 0.86 | MME (0.59) | MMEACESMN1; SMN2CPA1ACE2 | |
| SCHEMBL10798595 | 0.84 | GAA (0.52) | MMERAB9AGAAACEKMT2A | |
| SCHEMBL7432462 | 0.81 | MME (0.68) | MMEACECPA1ACE2 | |
| SCHEMBL3710422 | 0.81 | MME (0.64) | MMEACECPA1ACE2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5101039-A | Carboxyindoles, hypotensive agents, inhibitors of angiotensin converting enzyme | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-5061722-A | Hypotensive agents; e.g. ramipril | HOECHST AG (DE) | 1991-10-29 | — | — | US | disclosed |
| US-5053519-A | Hypotensive agents; diuretics; vasodilation | HOECHST AG (DE) | 1991-10-01 | — | — | US | disclosed |
| US-5008400-A | Chemical intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |
| US-4933361-A | HYPOTENSIVE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4879403-A | AMINATION, CRYSTALLIZATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-07 | — | — | US | disclosed |
| US-4727160-A | HYPOTENSIVE INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-23 | — | — | US | disclosed |
| US-4714708-A | Derivatives of cis, endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid, and their use for treating hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-12-22 | — | — | US | disclosed |
| EP-0111873-B1 | DERIVATIVES OF CIS, ENDO-2-AZABICYCLO-(5.3.0)-DECANE-3-CARBOXYLIC ACID, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-07 | — | — | EP | disclosed |
| EP-0170775-A1 | Derivatives of bicyclic amino acids, processes for their preparation, agents containing them and their use as well as bicyclic amino acids as intermediates and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-02-12 | — | — | EP | disclosed |
| EP-0150263-A1 | Derivatives of cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acid, process for their preparation, medicaments containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-08-07 | — | — | EP | disclosed |
| EP-0090362-A2 | Derivatives of cycloalka(c)pyrrole-carboxylic acids, process for their preparation, agents containing them and their use, as well as cycloalka(c)pyrrole-carboxylic acids as intermediates, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-10-05 | — | — | EP | disclosed |
| EP-0084164-A2 | Derivatives of bicyclic amino acids, process for their preparation, agents containing them and their use, as well as bicyclic amino acids as intermediates, and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-27 | — | — | EP | disclosed |
| EP-0079022-A2 | Derivatives of cis, endo-2-azabicyclo-(3.3.0)-octane-3-carboxylic acid, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-05-18 | — | — | EP | disclosed |