Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733346 | 1.00 | RAB9A (0.52) | RAB9AGAAMMELMNAL3MBTL1 | |
| SCHEMBL9864316 | 1.00 | RAB9A (0.52) | RAB9AGAAMMELMNAL3MBTL1 | |
| SCHEMBL7280394 | 0.91 | MME (0.62) | RAB9AGAAMMELMNASIGMAR1 | |
| SCHEMBL7280398 | 0.91 | MME (0.62) | RAB9AGAAMMELMNASIGMAR1 | |
| SCHEMBL9733367 | 0.91 | MME (0.62) | RAB9AGAAMMELMNASIGMAR1 | |
| SCHEMBL19465106 | 0.86 | GAA (0.56) | RAB9AGAAMMELMNAL3MBTL1 | |
| SCHEMBL10655994 | 0.86 | GAA (0.52) | RAB9AGAAMMELMNAL3MBTL1 | |
| SCHEMBL7439231 | 0.86 | TACR1 (0.58) | CTSLCTSBTACR1MAPTACE | |
| SCHEMBL16116809 | 0.83 | GAA (0.58) | RAB9AGAAMMEL3MBTL1LTA4H | |
| SCHEMBL8366724 | 0.83 | GAA (0.61) | RAB9AGAACTSLCTSBTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061722-A | Hypotensive agents; e.g. ramipril | HOECHST AG (DE) | 1991-10-29 | — | — | US | disclosed |
| US-5053519-A | Hypotensive agents; diuretics; vasodilation | HOECHST AG (DE) | 1991-10-01 | — | — | US | disclosed |
| US-4879403-A | AMINATION, CRYSTALLIZATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-07 | — | — | US | disclosed |
| US-4727160-A | HYPOTENSIVE INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-23 | — | — | US | disclosed |
| EP-0111873-B1 | DERIVATIVES OF CIS, ENDO-2-AZABICYCLO-(5.3.0)-DECANE-3-CARBOXYLIC ACID, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-07 | — | — | EP | disclosed |
| EP-0150263-A1 | Derivatives of cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acid, process for their preparation, medicaments containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-08-07 | — | — | EP | disclosed |