Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | ME2 | P23368 | 1/20 | 0.60 |
| ▸ | ME1 | P48163 | 1/20 | 0.60 |
| ▸ | ME3 | Q16798 | 1/20 | 0.60 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131839 | 0.86 | NPC1 (0.86) | NPC1TDP1TSHRL3MBTL1ME2 | |
| SCHEMBL13315137 | 0.84 | GRM5 (0.73) | GRM5NPC1TDP1 | |
| SCHEMBL13504007 | 0.84 | GRM5 (0.72) | GRM5TDP1L3MBTL1POLB | |
| SCHEMBL7278874 | 0.83 | SIGMAR1 (0.67) | GRM5TSHR | |
| SCHEMBL4830376 | 0.83 | GRM5 (0.71) | GRM5NPC1TDP1POLB | |
| SCHEMBL1946924 | 0.82 | GRM5 (0.70) | GRM5POLB | |
| SCHEMBL1902638 | 0.82 | GRM5 (1.00) | GRM5NPC1ME2ME1ME3 | |
| SCHEMBL13548728 | 0.82 | L3MBTL1 (0.79) | NPC1TDP1TSHRL3MBTL1ME2 | |
| SCHEMBL21322119 | 0.81 | GRM5 (0.60) | GRM5NPC1TDP1TSHRL3MBTL1 | |
| SCHEMBL1824981 | 0.81 | GRM5 (0.68) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281598-A | Psychological disorders | AKZO N.V. (NL) | 1994-01-25 | — | — | US | disclosed |
| EP-0566189-A1 | Psychotropic piperazine derivative | AKZO N.V. (NL) | 1993-10-20 | — | — | EP | disclosed |