Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284790 | 0.90 | OPRK1 (0.48) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7273374 | 0.90 | OPRK1 (0.48) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL9069239 | 0.90 | OPRK1 (0.48) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7279559 | 0.89 | POLB (0.46) | ALDH1A1POLBTDP1ACE | |
| SCHEMBL7282549 | 0.85 | MAPT (0.57) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7281772 | 0.82 | TACR1 (0.50) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7266031 | 0.82 | POLB (0.58) | TACR1MAPTPOLBTDP1CYP3A4 | |
| SCHEMBL7336421 | 0.81 | TACR1 (0.53) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7273779 | 0.79 | TACR1 (0.51) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL9069023 | 0.78 | TACR2 (0.49) | TACR1MAPTALDH1A1RECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |