Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9069239 | 1.00 | OPRK1 (0.48) | OPRK1TACR1MAPTALDH1A1RECQL | |
| SCHEMBL7284790 | 1.00 | OPRK1 (0.48) | OPRK1TACR1MAPTALDH1A1RECQL | |
| SCHEMBL7280682 | 0.90 | TACR1 (0.44) | OPRK1TACR1MAPTALDH1A1RECQL | |
| SCHEMBL9068639 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HRH3POLBTDP1 | |
| SCHEMBL7282932 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HRH3POLBTDP1 | |
| SCHEMBL7283853 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HRH3POLBTDP1 | |
| SCHEMBL7282549 | 0.87 | MAPT (0.57) | TACR1MAPTALDH1A1RECQLHRH3 | |
| SCHEMBL7281772 | 0.84 | TACR1 (0.50) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7336421 | 0.82 | TACR1 (0.53) | TACR1MAPTALDH1A1RECQLPOLB | |
| SCHEMBL7337799 | 0.81 | POLB (0.60) | TACR1MAPTATML3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |