Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.46 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280701 | 0.89 | REN (0.47) | RENHTRA1 | |
| SCHEMBL7280707 | 0.84 | REN (0.46) | RENHTRA1 | |
| SCHEMBL7299478 | 0.83 | CTSS (0.41) | REN | |
| SCHEMBL10592277 | 0.83 | CTSS (0.41) | REN | |
| SCHEMBL10521190 | 0.81 | REN (0.59) | RENHTRA1CTSL | |
| SCHEMBL9770950 | 0.81 | REN (0.59) | RENHTRA1CTSL | |
| SCHEMBL7299961 | 0.79 | REN (0.48) | REN | |
| SCHEMBL7280041 | 0.77 | REN (0.46) | RENCTSL | |
| SCHEMBL7280909 | 0.76 | CTSS (0.40) | REN | |
| SCHEMBL7281024 | 0.76 | CTSS (0.40) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |