Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.87 |
| ▸ | HPGD | P15428 | 2/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.87 |
| ▸ | PDE5A | O76074 | 4/20 | 0.84 |
| ▸ | HTT | P42858 | 1/20 | 0.83 |
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.79 |
| ▸ | KDM1A | O60341 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062324 | 0.91 | PDE5A (1.00) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL1063103 | 0.86 | ABCG2 (1.00) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL15986596 | 0.86 | CYP1A2 (0.78) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15966650 | 0.85 | CYP1A2 (0.76) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL1083757 | 0.85 | MAPT (0.80) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL12316882 | 0.85 | ABCG2 (0.81) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL14727344 | 0.84 | CYP1A2 (0.73) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL20273653 | 0.84 | CYP1A2 (1.00) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL15977152 | 0.84 | CYP1A2 (0.75) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15966687 | 0.84 | ABCG2 (0.79) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| US-10934270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200071292-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2020-03-05 | — | — | US | disclosed |
| US-10167270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170217923-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-9630947-B2 | Therapeutic compounds and related methods of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-25 | — | — | US | disclosed |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2017-01-05 | — | — | US | disclosed |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2017-01-05 | — | — | US | disclosed |
| EP-2521549-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2016-08-17 | — | — | EP | disclosed |
| US-20150307477-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | GALENEA CORPORATION | 2015-10-29 | — | — | US | disclosed |
| US-9073890-B2 | Therapeutic compounds and related methods of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| US-20130053341-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL COMPANY (JP) | 2013-02-28 | — | — | US | disclosed |
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | OSI PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5439895-A | Cardiovascular disorders; inhibitor of thromboxane A2 synthetase and cyclic guanosine 3',5'-monophosphate | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5436233-A | Nervous system disorders | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307477-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PTPRG, PPP2CA | CYP1A2 4552/4885CYP3A4 4815/4885TSHR 2177/4885 |
| US-10934270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GAA, GBA2 | CYP1A2 2508/4885CYP3A4 2684/4885TSHR 4206/4885 |
| US-20200071292-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GAA, GBA2 | CYP1A2 2508/4885CYP3A4 2684/4885TSHR 4206/4885 |
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | VHL, MCL1, NFATC1 | CYP1A2 1452/4885CYP3A4 834/4885TSHR 4097/4885 |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GAA, GBA2 | CYP1A2 2508/4885CYP3A4 2684/4885TSHR 4206/4885 |
| US-10167270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GAA, GBA2 | CYP1A2 2508/4885CYP3A4 2684/4885TSHR 4206/4885 |
| US-20130053341-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PPP3CB, PTPRG | CYP1A2 4619/4885CYP3A4 4805/4885TSHR 2340/4885 |
| US-20170217923-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PTPRG, PPP2CA | CYP1A2 4552/4885CYP3A4 4815/4885TSHR 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.