Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434721 | 0.86 | CPA1 (0.57) | LTA4HCYP1A2MMEANPEPECE1 | |
| SCHEMBL7280073 | 0.86 | CPA1 (0.57) | LTA4HCYP1A2MMEANPEPECE1 | |
| SCHEMBL9574213 | 0.79 | ABCB1 (0.57) | SLC15A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7320025 | 0.79 | ALDH1A1 (0.56) | SLC15A1LTA4HCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7320029 | 0.79 | ALDH1A1 (0.56) | SLC15A1LTA4HCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17617234 | 0.78 | CYP1A2 (0.58) | EPHX2PPARGSLC15A1LTA4HCYP1A2 | |
| SCHEMBL8399603 | 0.78 | CPA3 (0.66) | SLC15A1LTA4HCYP1A2ALDH1A1CTRB1 | |
| SCHEMBL7289839 | 0.78 | CPA3 (0.66) | SLC15A1LTA4HCYP1A2ALDH1A1CTRB1 | |
| SCHEMBL7354310 | 0.78 | CPA3 (0.66) | SLC15A1LTA4HCYP1A2ALDH1A1CTRB1 | |
| SCHEMBL21811160 | 0.76 | CYP1A2 (0.59) | SLC15A1LTA4HCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |