Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 6/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16967361 | 0.87 | LMNA (0.46) | TEAD1OPRD1CES2CES1MAOB | |
| SCHEMBL15797668 | 0.85 | TEAD1 (0.55) | TEAD1CES2CES1SLC6A4CACNA1A | |
| SCHEMBL7441378 | 0.84 | TEAD1 (0.54) | TEAD1OPRD1CES2CES1SLC6A4 | |
| SCHEMBL15797586 | 0.83 | TEAD1 (0.58) | TEAD1CES2CES1 | |
| SCHEMBL15129215 | 0.82 | TEAD1 (0.52) | TEAD1OPRD1CES2CES1CACNA1A | |
| SCHEMBL7278992 | 0.81 | CYP2D6 (0.58) | OPRD1SLC6A4 | |
| SCHEMBL7278715 | 0.81 | OPRD1 (0.50) | OPRD1 | |
| SCHEMBL793646 | 0.80 | OPRD1 (0.60) | OPRD1SLC6A4GAA | |
| SCHEMBL7289195 | 0.80 | OPRD1 (0.40) | TEAD1OPRD1SLC6A4TACR1 | |
| SCHEMBL7292313 | 0.79 | TACR1 (0.40) | TEAD1OPRD1SLC6A4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |