Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272936 | 0.87 | CNR2 (0.52) | CNR2PTPN11CNR1 | |
| SCHEMBL7278447 | 0.85 | PTPN11 (0.59) | PTPN11 | |
| SCHEMBL3756924 | 0.78 | NOS1 (0.66) | CNR2PTPN11PIK3CA | |
| SCHEMBL7714561 | 0.78 | KDM4E (0.56) | DHFRPIK3CA | |
| SCHEMBL23019331 | 0.78 | PIK3CA (0.49) | DHFRPIK3CA | |
| SCHEMBL7708544 | 0.78 | NOS1 (0.58) | DHFRPIK3CALRRK2 | |
| SCHEMBL6049559 | 0.73 | FGFR1 (0.49) | PTPN11DHFR | |
| SCHEMBL975784 | 0.73 | CYP2D6 (0.57) | PTPN11DHFR | |
| SCHEMBL7712374 | 0.73 | PIK3CA (0.48) | DHFRPIK3CA | |
| SCHEMBL7712422 | 0.73 | STK4 (0.54) | DHFRPIK3CALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |