Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.54 |
| ▸ | STK4 | Q13043 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714561 | 0.86 | KDM4E (0.56) | PIK3CAMTORPIK3R1DHFRPIK3CD | |
| SCHEMBL7712422 | 0.86 | STK4 (0.54) | PIK3CAMTORPIK3R1STK4STK3 | |
| SCHEMBL7712374 | 0.86 | PIK3CA (0.48) | NOS1PIK3CAMTORPIK3R1DHFR | |
| SCHEMBL4560009 | 0.83 | HRH4 (0.54) | DHFR | |
| SCHEMBL2167151 | 0.83 | HRH4 (0.61) | DHFRHSD17B10 | |
| SCHEMBL3721578 | 0.83 | TRPM8 (0.59) | NOS1PIK3CAMTORPIK3R1STK4 | |
| SCHEMBL13650807 | 0.79 | NOS1 (0.60) | NOS1PIK3CASTK4STK3LRRK2 | |
| SCHEMBL7282145 | 0.78 | CNR2 (0.56) | PIK3CALRRK2DHFR | |
| SCHEMBL18335242 | 0.77 | DHFR (0.56) | NOS1PIK3CAMTORPIK3R1DHFR | |
| SCHEMBL8133822 | 0.77 | CTSK (0.51) | NOS1PIK3CAMTORPIK3R1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025091-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM | Krenitsky Pharmaceuticals, Inc. (US) | 2000-08-09 | — | — | EP | claimed |
| WO-1999019305-A2 | SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM | KRENITSKY PHARMACEUTICALS INC. (US) | 1999-04-22 | — | — | WO | claimed |
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |