SCHEMBL7282256

SCHEMBL7282256

COC(=O)C1=C(C)Nc2c(c(C(C)(C)C)nn2C)C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 0.62
CACNA1C Q13936 6/20 0.62
CYP1A2 P05177 5/20 0.62
MAPT P10636 5/20 0.62
CYP3A4 P08684 4/20 0.62
CYP2C9 P11712 4/20 0.62
CYP2C19 P33261 4/20 0.62
CACNA1F O60840 3/20 0.62
CACNA1D Q01668 3/20 0.62
CACNA1S Q13698 3/20 0.62
TSHR P16473 3/20 0.62
NFKB1 P19838 3/20 0.62
KMT2A Q03164 3/20 0.62
ABCC4 O15439 2/20 0.62
ABCB11 O95342 2/20 0.62
LMNA P02545 2/20 0.62
ADORA2A P29274 2/20 0.62
ADORA1 P30542 2/20 0.62
OPRM1 P35372 2/20 0.62
SCN1A P35498 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7271051 0.91 ACHE (0.53) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7272968 0.90 CACNA1C (0.50) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7282056 0.89 CACNA1C (0.67) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7271467 0.85 KDM4E (0.41) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7282419 0.85 ADORA3 (0.62) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7278723 0.85 ADORA3 (0.62) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7273553 0.84 ADORA3 (0.60) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7271327 0.83 CACNA1C (0.60) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7438220 0.83 ADORA3 (0.59) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7278736 0.82 ADORA3 (0.58) ADORA3CACNA1CCYP1A2MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0114273-B1 NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES GRUPPO LEPETIT S.p.A. (IT) 1991-11-06 EP disclosed
US-4954508-A HYPOTENSIVE GRUPPO LEPETIT S.P.A. (IT) 1990-09-04 US disclosed