SCHEMBL7438220

SCHEMBL7438220

COC(=O)C1=C(C)Nc2c(c(C3CCCC3)nn2C)C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 0.59
CACNA1C Q13936 6/20 0.59
CYP1A2 P05177 5/20 0.59
MAPT P10636 5/20 0.59
CYP3A4 P08684 4/20 0.59
CYP2C9 P11712 4/20 0.59
CYP2C19 P33261 4/20 0.59
LMNA P02545 3/20 0.59
TSHR P16473 3/20 0.59
NFKB1 P19838 3/20 0.59
KMT2A Q03164 3/20 0.59
ABCC4 O15439 2/20 0.59
CACNA1F O60840 2/20 0.59
ABCB11 O95342 2/20 0.59
ADORA2A P29274 2/20 0.59
ADORA1 P30542 2/20 0.59
OPRM1 P35372 2/20 0.59
SCN1A P35498 2/20 0.59
HTR2B P41595 2/20 0.59
CACNA1D Q01668 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7282351 0.99 ADORA3 (0.58) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10379001 0.91 ADORA3 (0.48) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10378577 0.91 LMNA (0.48) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7278700 0.91 ACHE (0.55) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10378569 0.91 ADORA3 (0.47) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10377721 0.90 CACNA1C (0.44) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10377722 0.90 CACNA1C (0.44) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL10956329 0.90 CACNA1C (0.47) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL7281461 0.90 LMNA (0.47) ADORA3CACNA1CCYP1A2MAPTCYP3A4
SCHEMBL11002568 0.89 CACNA1C (0.55) ADORA3CACNA1CCYP1A2MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0355234-A1 Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1990-02-28 EP claimed
EP-0107619-B1 DIHYDROPYRAZOLO(3,4-B)PYRIDINE DERIVATIVES AND PRODUCTION THEREOF SHIONOGI & CO., LTD. (JP) 1987-07-29 EP claimed
EP-0107619-A1 Dihydropyrazolo(3,4-b)pyridine derivatives and production thereof SHIONOGI & CO., LTD. (JP) 1984-05-02 EP claimed
US-4873334-A HYPOTENSIVE AGENTS, CORONARY VASODILATORS SHIONOGI & CO., LTD. (JP) 1989-10-10 US disclosed
EP-0107619-B1 DIHYDROPYRAZOLO(3,4-B)PYRIDINE DERIVATIVES AND PRODUCTION THEREOF SHIONOGI & CO., LTD. (JP) 1987-07-29 EP disclosed
EP-0107619-A1 Dihydropyrazolo(3,4-b)pyridine derivatives and production thereof SHIONOGI & CO., LTD. (JP) 1984-05-02 EP disclosed