Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282068 | 0.98 | SIGMAR1 (0.45) | SIGMAR1CACNA1GNPSR1CA12CA1 | |
| SCHEMBL7274234 | 0.96 | SIGMAR1 (0.44) | SIGMAR1CACNA1GNPSR1ACEALDH1A1 | |
| SCHEMBL7276087 | 0.96 | SIGMAR1 (0.45) | SIGMAR1CACNA1GNPSR1CA12CA1 | |
| SCHEMBL7275657 | 0.95 | SIGMAR1 (0.46) | SIGMAR1CACNA1GCA1CA2S1PR1 | |
| SCHEMBL7284966 | 0.94 | SUCNR1 (0.42) | SIGMAR1CACNA1GCA12CA1CA2 | |
| SCHEMBL7276578 | 0.93 | SIGMAR1 (0.43) | SIGMAR1NPSR1CA12CA1CA2 | |
| SCHEMBL7282506 | 0.92 | SIGMAR1 (0.45) | SIGMAR1CACNA1GNPSR1ACE | |
| SCHEMBL7274737 | 0.92 | SIGMAR1 (0.43) | SIGMAR1CACNA1GALDH1A1LMNAMAPT | |
| SCHEMBL7283476 | 0.91 | SIGMAR1 (0.45) | SIGMAR1CACNA1GNPSR1CA12CA1 | |
| SCHEMBL7282728 | 0.90 | SIGMAR1 (0.40) | SIGMAR1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |