Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274358 | 0.98 | SIGMAR1 (0.44) | SIGMAR1NPSR1CACNA1GCA12CA1 | |
| SCHEMBL7275517 | 0.96 | SIGMAR1 (0.43) | SIGMAR1NPSR1 | |
| SCHEMBL7282368 | 0.96 | SIGMAR1 (0.44) | SIGMAR1NPSR1CA12CA1CA2 | |
| SCHEMBL7280624 | 0.95 | SIGMAR1 (0.45) | SIGMAR1CA1CA2FNTAFNTB | |
| SCHEMBL7275258 | 0.94 | CA12 (0.41) | SIGMAR1CACNA1GCA12CA1CA2 | |
| SCHEMBL7272287 | 0.93 | SIGMAR1 (0.42) | SIGMAR1NPSR1CA12CA1CA2 | |
| SCHEMBL7281590 | 0.92 | SIGMAR1 (0.44) | SIGMAR1NPSR1CACNA1G | |
| SCHEMBL7368900 | 0.91 | SIGMAR1 (0.42) | SIGMAR1NPSR1 | |
| SCHEMBL7283236 | 0.91 | SIGMAR1 (0.46) | SIGMAR1NPSR1CACNA1GCA12CA1 | |
| SCHEMBL7274557 | 0.90 | SIGMAR1 (0.44) | SIGMAR1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |