Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5902428 | 0.98 | SIGMAR1 (0.46) | KMT2AMEN1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL22882677 | 0.91 | MGAM (0.43) | KMT2AMEN1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL7236982 | 0.90 | KDM4E (0.49) | KMT2ACYP1A2CYP2D6KDM4E | |
| SCHEMBL10989633 | 0.83 | ALDH1A1 (0.54) | KMT2AKDM4EHPGD | |
| SCHEMBL64187 | 0.81 | KDM4E (0.50) | KMT2AMEN1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL9533341 | 0.81 | GAA (0.41) | CYP1A2KDM4EHPGD | |
| SCHEMBL12550776 | 0.81 | HRH3 (0.35) | SIGMAR1CYP1A2CYP2D6TSHRHPGD | |
| SCHEMBL64545 | 0.81 | KMT2A (0.51) | KMT2AMEN1KDM4EPSMB1PSMB5 | |
| SCHEMBL12014417 | 0.81 | KMT2A (0.45) | KMT2AMEN1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL9253983 | 0.79 | ALDH1A1 (0.51) | KMT2AMEN1SIGMAR1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0218996-A2 | Dihydropyridine derivative, a process for the production thereof and pharmaceutical compositions therefrom | YASON S.r.l (IT) | 1987-04-22 | — | — | EP | claimed |
| US-4826856-A | HYPOTENSIVE, ANTIISCHEMIC, ANTIARRHYTHMIA | YASON S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| US-4826856-A | HYPOTENSIVE, ANTIISCHEMIC, ANTIARRHYTHMIA | YASON S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0218996-A2 | Dihydropyridine derivative, a process for the production thereof and pharmaceutical compositions therefrom | YASON S.r.l (IT) | 1987-04-22 | — | — | EP | disclosed |
| EP-0218996-A2 | Dihydropyridine derivative, a process for the production thereof and pharmaceutical compositions therefrom | YASON S.r.l (IT) | 1987-04-22 | — | — | EP | disclosed |
| US-4551467-A | Vasodilating cyanoalkyl esters of 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1985-11-05 | — | — | US | disclosed |
| US-4044141-A | CORONARY DILATING, SPASMOLYTIC, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-08-23 | — | — | US | disclosed |