Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 8/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 7/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28987042 | 0.80 | SRC (0.33) | SRCKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7284511 | 0.79 | NOS2 (0.54) | SYKCCR1CCR5CCR8KDM4E | |
| SCHEMBL14680553 | 0.79 | MAPT (0.35) | CCR1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL25457192 | 0.79 | KDM4E (0.38) | CCR5MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL28097358 | 0.79 | SYK (0.36) | SYKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28065263 | 0.77 | KDM4E (0.31) | KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28293574 | 0.77 | MAPT (0.34) | CCR1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL827951 | 0.77 | SYK (0.48) | SYKAURKBINCENPUHRF1CCR1 | |
| Ethoxycarbonyl Group SCHEMBL27868094 | 0.77 | SMN1; SMN2 (0.38) | SRCSYKAURKBINCENPUHRF1 | |
| SCHEMBL4030600 | 0.76 | UHRF1 (0.45) | SYKAURKBINCENPUHRF1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |