Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308341 | 0.84 | MAPT (0.39) | KCNH2TDP2TDP1PDE3BPDE3A | |
| SCHEMBL4215079 | 0.82 | MAOB (0.43) | CYP3A4CYP1A2CYP2C9CYP2C19KCNH2 | |
| SCHEMBL7355155 | 0.81 | KCNH2 (0.44) | KCNH2PDE3BPDE3ADDB1CRBN | |
| SCHEMBL4361638 | 0.81 | AXL (0.52) | KCNH2ALDH1A1TDP1PDE3BPDE3A | |
| SCHEMBL10803822 | 0.78 | KDM4E (0.41) | MAPK1TDP2ALDH1A1TP53CRBN | |
| SCHEMBL10799782 | 0.78 | NOTUM (0.40) | PDE3BPDE3ADDB1CRBNKMT2A | |
| SCHEMBL10802190 | 0.77 | MAPT (0.42) | CYP3A4CYP1A2ALDH1A1TDP1LMNA | |
| SCHEMBL22309145 | 0.75 | PDE3B (0.42) | PDE3BPDE3A | |
| SCHEMBL4211464 | 0.75 | PDE3B (0.51) | ALDH1A1PDE3BPDE3AUSP2ALOX12 | |
| SCHEMBL22308344 | 0.75 | PDE3B (0.41) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383449-B1 | Pyridazinone derivatives and processes for preparing the same | ORION YHTYMAE OY (FI) | 1995-09-06 | — | — | EP | disclosed |
| US-5185332-A | Treating congestive heart failure | ORION-YHTYMA OY (FI) | 1993-02-09 | — | — | US | disclosed |
| US-5122524-A | Treatment for congestive heart failure; hypertensive agents; vasodilation | ORION-YHTYMA OY (FI) | 1992-06-16 | — | — | US | disclosed |
| US-5019575-A | Congestive Heart Failure Treatment | ORION-YHTYMA OY (FI) | 1991-05-28 | — | — | US | disclosed |
| EP-0383449-A2 | Pyridazinone derivatives and processes for preparing the same | ORION-YHTYMÀ OY (FI) | 1990-08-22 | — | — | EP | disclosed |
| US-4683232-A | N,N-DIMETHYL-P-(2,3-DIHYDRO-2-OXO-6H-1,3,4 OXADIAZIN-2-YLBENZAMIDE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-28 | — | — | US | disclosed |
| US-4587246-A | CARDIOTONIC | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-05-06 | — | — | US | disclosed |
| EP-0052442-B1 | HETEROCYCLIC COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-09-11 | — | — | EP | disclosed |
| US-4503054-A | VASODILATORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-03-05 | — | — | US | disclosed |
| US-4423045-A | CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-12-27 | — | — | US | disclosed |
| EP-0052442-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-05-26 | — | — | EP | disclosed |