Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577438 | 0.80 | HRH3 (0.35) | HRH3EPHX2AKT1DRD2PPIA | |
| SCHEMBL7272786 | 0.79 | AKT1 (0.42) | HRH3F10EPHX2AKT1S1PR1 | |
| SCHEMBL8417046 | 0.77 | AKT2 (0.45) | HRH3EPHX2AKT1S1PR1SIGMAR1 | |
| SCHEMBL27397736 | 0.76 | MEN1 (0.51) | HRH3S1PR1SIGMAR1HDAC1OPRM1 | |
| SCHEMBL7280838 | 0.76 | HDAC1 (0.44) | HRH3EPHX2S1PR1HDAC1 | |
| SCHEMBL7281838 | 0.75 | HRH3 (0.44) | HRH3EPHX2S1PR1HDAC1 | |
| SCHEMBL7283243 | 0.75 | HRH3 (0.44) | HRH3EPHX2S1PR1HDAC1 | |
| SCHEMBL7283131 | 0.74 | HRH3 (0.43) | HRH3EPHX2S1PR1HDAC1 | |
| SCHEMBL7280993 | 0.74 | HDAC1 (0.46) | HRH3S1PR1HDAC1 | |
| Hydrochloric Acid SCHEMBL7282229 | 0.74 | HRH3 (0.43) | HRH3EPHX2S1PR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |