Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.62 |
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172204 | 0.95 | MAOB (0.60) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL6507891 | 0.91 | MAOB (0.64) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL4216340 | 0.87 | LMNA (0.60) | MAOBBCHEMAOANR4A2ALOX5 | |
| SCHEMBL17911614 | 0.85 | KCNA3 (0.48) | MAOBMAOA | |
| SCHEMBL1268719 | 0.85 | MAOB (0.81) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL19281462 | 0.85 | CYP4F2 (0.66) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL5162745 | 0.84 | MAOB (0.68) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL8060184 | 0.83 | MAOB (0.62) | MAOBBCHECYP4F2CYP4A11MAOA | |
| SCHEMBL24648592 | 0.82 | KDM4E (0.56) | — | |
| SCHEMBL1172641 | 0.82 | MGLL (0.59) | MAOBBCHEMAOANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |