Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728015 | 0.88 | KDM4E (0.45) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL27295800 | 0.73 | TAS1R3 (0.56) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL1680291 | 0.72 | ALDH1A1 (0.59) | HTTALOX15CREBBPPSMB8KDM4E | |
| SCHEMBL11781256 | 0.72 | CA12 (0.49) | CA1CA2CA12CA7CA9 | |
| SCHEMBL28562583 | 0.71 | MAPT (0.54) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL7474034 | 0.71 | HTT (0.46) | HTTALOX15CA1CA2CA12 | |
| SCHEMBL2361382 | 0.71 | MAPT (0.54) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL1101431 | 0.71 | MAPT (0.54) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL31430581 | 0.71 | MAPT (0.54) | HTTALOX15CREBBPCA1CA2 | |
| SCHEMBL70757 | 0.69 | CREBBP (0.57) | HTTALOX15CREBBPCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| CN-1037519-A | HETEROCYCLIC KETONES | ICI AMERICA INC (US) | 1989-11-29 | — | — | CN | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |