Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286089 | 1.00 | REN (0.53) | RENHRH4PSMB5MMP2MMP9 | |
| SCHEMBL10422508 | 0.86 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10422511 | 0.85 | REN (0.48) | RENHRH4MMP2MMP9MMP8 | |
| Water SCHEMBL10422512 | 0.85 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10866334 | 0.85 | HRH4 (0.55) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10866332 | 0.85 | HRH4 (0.55) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10421161 | 0.83 | REN (0.49) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10421173 | 0.82 | REN (0.46) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10572007 | 0.82 | REN (0.59) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10772032 | 0.81 | REN (0.64) | RENPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |