Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29144762 | 0.84 | CA1 (0.56) | POLBCA12CA1CA2CA9 | |
| SCHEMBL28667831 | 0.82 | POLB (0.51) | EPAS1POLBKMT2ACA12CA1 | |
| SCHEMBL18513397 | 0.81 | PTPN1 (0.53) | EPAS1POLBMEN1KMT2ACA12 | |
| SCHEMBL22662913 | 0.80 | PTPN11 (0.51) | PLAUPOLBPTPN11LCKCA12 | |
| SCHEMBL3316267 | 0.79 | STS (0.49) | PLAUPTPN11NOTUMLCKCA12 | |
| SCHEMBL69025 | 0.79 | PTPN11 (0.68) | PLAUPTPN11LCKMEN1KMT2A | |
| SCHEMBL29365729 | 0.79 | PTPN11 (0.68) | PLAUPTPN11LCKMEN1KMT2A | |
| SCHEMBL732953 | 0.78 | NOTUM (0.50) | EPAS1POLBNOTUMMEN1KMT2A | |
| SCHEMBL27367160 | 0.78 | CYP2C9 (0.52) | PLAUPOLBPTPN11LCKCYP2C9 | |
| SCHEMBL6002200 | 0.77 | EPAS1 (0.49) | EPAS1NOTUMMEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0744406-B1 | Cyclic peptide antifungal agents | LILLY CO ELI (US) | 2002-09-04 | — | — | EP | disclosed |
| US-5629290-A | Cyclic peptide antifungal agents | ELI LILLY AND COMPANY (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0744406-A2 | Cyclic peptide antifungal agents | ELI LILLY AND COMPANY (US) | 1996-11-27 | — | — | EP | disclosed |