Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208225 | 0.94 | GRIN2D (0.62) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7294820 | 0.93 | KDM4E (0.64) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7287564 | 0.88 | MAPT (0.68) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7286173 | 0.87 | LTA4H (0.67) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4692610 | 0.86 | GRIN2D (0.69) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6207790 | 0.86 | GRIN2D (0.57) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7290147 | 0.85 | GRIN2D (0.67) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7289245 | 0.83 | GRIN2D (0.79) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7295960 | 0.83 | GRIN2D (0.65) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6207263 | 0.83 | GRIN2D (0.78) | MAPTGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |