SCHEMBL6208225

SCHEMBL6208225

OC1(Cc2ccc(F)cc2)CCN(CCOc2ccc(OCc3ccccc3)cc2)CC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.62
GRIN3B O60391 1/20 0.62
MAPT P10636 1/20 0.62
GRIN1 Q05586 1/20 0.62
GRIN2A Q12879 1/20 0.62
GRIN2B Q13224 1/20 0.62
GRIN2C Q14957 1/20 0.62
GRIN3A Q8TCU5 1/20 0.62
LTA4H P09960 7/20 0.58
HTT P42858 2/20 0.56
KDM4E B2RXH2 4/20 0.51
HRH3 Q9Y5N1 2/20 0.49
KCNH2 Q12809 1/20 0.49
MCHR1 Q99705 1/20 0.49
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 2/20 0.48
NPSR1 Q6W5P4 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7290504 0.94 KDM4E (0.57) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL7286173 0.93 LTA4H (0.67) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL7295960 0.89 GRIN2D (0.65) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL7289245 0.89 GRIN2D (0.79) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL6207263 0.89 GRIN2D (0.78) GRIN2DGRIN3BMAPTGRIN1GRIN2A
Hydrochloric Acid SCHEMBL6207982 0.88 GRIN2D (0.78) GRIN2DGRIN3BMAPTGRIN1GRIN2A
Hydrochloric Acid SCHEMBL6207053 0.87 GRIN2D (0.77) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL7294820 0.87 KDM4E (0.64) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL6207318 0.86 GRIN2D (0.78) GRIN2DGRIN3BMAPTGRIN1GRIN2A
SCHEMBL6207626 0.86 GRIN2D (0.65) GRIN2DGRIN3BMAPTGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869792-B1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 2005-03-09 EP disclosed
EP-0824098-B1 4-hydroxy-piperidine derivatives HOFFMANN LA ROCHE (CH) 2001-10-31 EP disclosed
US-6284776-B1 ADMINISTERING N-METHYLASPARATIC ACID RECEPTOR ANTAGONIST MELTZER LEONARD T (US) 2001-09-04 US disclosed
US-6124323-A ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
EP-1024799-A1 METHOD FOR TREATING DISEASE-RELATED OR DRUG-INDUCED DYSKINESIAS WARNER-LAMBERT COMPANY (US) 2000-08-09 EP disclosed
EP-0869792-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-09-22 EP disclosed
WO-1999021539-A1 METHOD FOR TREATING DISEASE-RELATED OR DRUG-INDUCED DYSKINESIAS WARNER-LAMBERT COMPANY (US) 1999-05-06 WO disclosed
US-5889026-A 4-hydroxy-piperodine derivatives HOFFMANN-LA ROCHE INC. (US) 1999-03-30 US disclosed
EP-0869792-A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP disclosed
EP-0824098-A1 4-hydroxy-piperidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-02-18 EP disclosed
WO-1997023216-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed