Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436201 | 0.92 | PLAAT3 (0.60) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7274811 | 0.89 | ALDH1A1 (0.70) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL344964 | 0.84 | PPARG (0.54) | ALDH1A1LMNA | |
| SCHEMBL23417617 | 0.83 | ALDH1A1 (0.77) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL585819 | 0.81 | FFAR4 (0.60) | ALDH1A1LMNA | |
| Malonic Acid SCHEMBL8557894 | 0.80 | FFAR1 (0.56) | ALDH1A1LMNA | |
| SCHEMBL23392535 | 0.80 | MAPT (0.77) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7278495 | 0.80 | PLAAT3 (0.74) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4026085 | 0.80 | CA1 (0.69) | MEN1KMT2A | |
| SCHEMBL7357508 | 0.79 | POLB (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223598-B1 | CATECHOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FISONS plc (GB) | 1991-06-12 | — | — | EP | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| US-4883804-A | Aromatic compounds | FISONS PLC (GB) | 1989-11-28 | — | — | US | disclosed |
| EP-0223598-A2 | Catecholamine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-05-27 | — | — | EP | disclosed |