Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585819 | 0.95 | FFAR4 (0.60) | FFAR1FFAR4PPARAPPARDHTT | |
| SCHEMBL344964 | 0.87 | PPARG (0.54) | FFAR1FFAR4PPARAHTTLMNA | |
| SCHEMBL584916 | 0.85 | HTT (0.52) | HTTLMNAMAPK1RAB9AALOX5 | |
| SCHEMBL4208634 | 0.83 | FFAR1 (0.57) | FFAR1FFAR4PPARAPPARDFFAR2 | |
| SCHEMBL7847132 | 0.83 | RAB9A (0.58) | HTTLMNAMAPK1RAB9AALOX5 | |
| SCHEMBL657509 | 0.82 | KMT2A (0.50) | ALOX5OR51E2 | |
| SCHEMBL14892303 | 0.82 | HTT (0.54) | FFAR1FFAR4HTTLMNAMAPK1 | |
| SCHEMBL347209 | 0.81 | FFAR4 (0.61) | FFAR1FFAR4ALOX5OR51E2KDM4E | |
| SCHEMBL21359040 | 0.81 | FFAR4 (0.51) | FFAR1FFAR4PPARAPPARDLMNA | |
| SCHEMBL7286269 | 0.80 | ALDH1A1 (0.57) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885210-A1 | Tricylic compounds having binding affinity for melatonin receptors, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032871-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-12 | — | — | WO | disclosed |