Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534138 | 0.90 | KDM4E (0.55) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL16669624 | 0.86 | KDM4E (0.57) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL28819201 | 0.82 | KDM4E (0.58) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL729020 | 0.82 | NR4A2 (0.59) | LMNASMN1; SMN2PKMHSD17B10ALDH1A1 | |
| SCHEMBL15655586 | 0.81 | KDM4E (0.52) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL735160 | 0.81 | KDM4E (0.54) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL10840435 | 0.80 | ALDH1A1 (0.63) | KDM4ELMNAHSD17B10ALDH1A1KMT2A | |
| SCHEMBL16110074 | 0.78 | TUBB4A (0.61) | KDM4EPKMHSD17B10ALDH1A1MAPT | |
| SCHEMBL29744098 | 0.77 | KDM4E (0.53) | KDM4ELMNASMN1; SMN2PKMHSD17B10 | |
| SCHEMBL19193162 | 0.75 | KDM4E (0.60) | KDM4ELMNASMN1; SMN2PKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138173-B2 | Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-03-20 | — | — | US | disclosed |