Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287748 | 0.83 | NPBWR1 (0.52) | NPBWR1MCHR1L3MBTL1HTR1ADRD2 | |
| SCHEMBL7294686 | 0.77 | NPBWR1 (0.52) | NPBWR1MCHR1L3MBTL1HTR1ADRD2 | |
| SCHEMBL7296089 | 0.74 | NPBWR1 (0.52) | NPBWR1MCHR1L3MBTL1HTR1ANPC1 | |
| SCHEMBL7295617 | 0.74 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7295611 | 0.74 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7295032 | 0.73 | NPBWR1 (0.53) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7286486 | 0.73 | KMT2A (0.55) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7286482 | 0.73 | KMT2A (0.55) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7295039 | 0.73 | NPBWR1 (0.53) | NPBWR1MCHR1L3MBTL1DRD2NPC1 | |
| SCHEMBL7295538 | 0.73 | L3MBTL1 (0.59) | NPBWR1MCHR1L3MBTL1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |