Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295538 | 0.90 | L3MBTL1 (0.59) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7287116 | 0.87 | MAPT (0.48) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7293000 | 0.81 | NPBWR1 (0.48) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7296105 | 0.80 | NPBWR1 (0.45) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7286818 | 0.77 | L3MBTL1 (0.48) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7284217 | 0.77 | KMT2A (0.52) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7284221 | 0.77 | KMT2A (0.52) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL7286545 | 0.74 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1NPC1MAPT | |
| SCHEMBL11319437 | 0.74 | KMT2A (0.61) | MEN1KMT2AHPGDLMNAALDH1A1 | |
| SCHEMBL7295617 | 0.72 | NPBWR1 (0.54) | NPBWR1MCHR1L3MBTL1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810220-B1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6258953-B1 | Arylacrylamide derivatives | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0810220-A1 | Arylacrylamide derivatives as 5HT1 agonists or antagonists | PFIZER INC. (US) | 1997-12-03 | — | — | EP | disclosed |