Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.67 |
| ▸ | CTSS | P25774 | 5/20 | 0.67 |
| ▸ | CTSL | P07711 | 2/20 | 0.67 |
| ▸ | CTSB | P07858 | 1/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.65 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067668 | 0.92 | CTSK (0.77) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL7402633 | 0.86 | CTSK (0.76) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL5934709 | 0.86 | CTSK (0.76) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL7411658 | 0.86 | CTSK (0.76) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL11361534 | 0.86 | CTSK (0.76) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL24115146 | 0.84 | CTSK (0.73) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL4669748 | 0.84 | CTSK (0.73) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL20669315 | 0.84 | CTSK (0.73) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL9115066 | 0.84 | CAPN1 (0.80) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL7158258 | 0.83 | CTSK (0.71) | CTSKCTSSCTSLCTSBCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236872-B1 | HYDROXYL AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-25 | — | — | EP | disclosed |
| US-4996358-A | Control, prevention rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0236872-A2 | Hydroxyl amine derivatives, their preparation and use as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-16 | — | — | EP | disclosed |