Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.51 |
| ▸ | REN | P00797 | 5/20 | 0.44 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.43 |
| ▸ | FCER2 | P06734 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286963 | 1.00 | PSMB5 (0.51) | PSMB5RENMMP2MMP9MMP1 | |
| SCHEMBL7285491 | 0.88 | CTSS (0.50) | PSMB5RENMMP1FCER2CTSL | |
| SCHEMBL7285504 | 0.88 | CTSS (0.50) | PSMB5RENMMP1FCER2CTSL | |
| SCHEMBL7442083 | 0.86 | REN (0.40) | PSMB5RENMMP2MMP9MMP1 | |
| SCHEMBL7287096 | 0.85 | REN (0.55) | RENCTSD | |
| SCHEMBL7287101 | 0.85 | REN (0.55) | RENCTSD | |
| SCHEMBL7296225 | 0.83 | CTSS (0.56) | RENACECTSLCTSBCTSS | |
| SCHEMBL7268466 | 0.83 | CTSS (0.56) | RENACECTSLCTSBCTSS | |
| SCHEMBL7286309 | 0.83 | TACR1 (0.54) | CTSLCTSBCTSS | |
| SCHEMBL7286303 | 0.83 | TACR1 (0.54) | CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264106-B1 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | BANYU PHARMA CO LTD (JP) | 1994-03-16 | — | — | EP | disclosed |
| US-4851387-A | RENIN INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0264106-A2 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-04-20 | — | — | EP | disclosed |